162285-06-5Relevant academic research and scientific papers
Parallel synthesis of homochiral β-amino acids
Davies, Stephen G.,Mulvaney, Andrew W.,Russell, Angela J.,Smith, Andrew D.
, p. 1554 - 1566 (2008/02/09)
The parallel asymmetric synthesis of an array of 30 β-amino acids of high enantiomeric purity using the conjugate addition of homochiral lithium N-benzyl-N-(α-methylbenzyl)amide as the key step is accomplished. The experimental simplicity and highly practical nature of the protocol is demonstrated by the efficient parallel conversion of 15 α,β-unsaturated esters to both enantiomeric series of the corresponding β-amino acids in high overall yields and selectivities with minimal purification involved in each step of the reaction protocol.
Asymmetric Synthesis of the N-terminal component of Microginin: (2S,3R)-3-Amino-2-Hydroxydecanoic Acid, its (2R,3R)-Epimer and (3R)-Aminodecanoic Acid
Bunnage, Mark E.,Burke, Anthony J.,Davies, Stephen G.,Goodwin, Christopher J.
, p. 165 - 176 (2007/10/02)
3-Amino-2-hydroxydecanoic acid (AHDA) is a novel amino acid which has been suggested as the N-terminal component of the recently isolated angiotensin-converting enzyme inhibitor microginin.The naturally occurring amino acid was found to possess syn relati
