162302-14-9Relevant academic research and scientific papers
Synthesis, structure-activity relationships, and the effect of polyethylene glycol on inhibitors of phosphatidylinositol-specific phospholipase C from Bacillus cereus
Ryan, Margret,Smith, Miles P.,Vinod, Thottumkara K.,Lau, Wai Leung,Keana, John F. W.,Griffith, O. Hayes
, p. 4366 - 4376 (2007/10/03)
Substrate analog inhibitors of Bacillus cereus phosphatidylinositol- specific phospholipase C (PI-PLC) were synthesized and screened for their suitability to map the active site region of the enzyme by protein crystallography. Analogs of the natural subst
Parasite glycoconjugates. Part 3. Synthesis of substrate analogues of early intermediates in the biosynthetic pathway of glycosylphosphatidylinositol membrane anchors
Cottaz, Sylvain,Brimacombe, John S.,Ferguson, Michael A. J.
, p. 1673 - 1678 (2007/10/02)
Substrate analogues of sodium 1D-6-O-(2-acetamido-2-deoxy-α-D-glucopyranosyl)-myo-inositol 1- 3, including the lipid-depleted compounds 9, 11 and 15, have been prepared for biological evaluation with a partially purified de-N-acetylase from the bloodstream form of the parasitic protozoan Trypanosoma brucei.Such analogues as 2-deoxy-α-D-Glcp-PI 25 and α-D-Glcp-PI 33 have also been prepared and tested as potential inhibitors of this de-N-acetylase.
