1623102-50-0

Basic information

• Product Name: ethyl{[6-chloro-1-(4-ethoxyphenyl)-4-methoxy-1H-benzimidazol-2-yl]amino}acetate
• Synonyms: ethyl{[6-chloro-1-(4-ethoxyphenyl)-4-methoxy-1H-benzimidazol-2-yl]amino}acetate
• CAS NO: 1623102-50-0
• Molecular Weight: 403.865
• Mol File: 1623102-50-0.mol

Chemical Properties

• CAS DataBase Reference: ethyl{[6-chloro-1-(4-ethoxyphenyl)-4-methoxy-1H-benzimidazol-2-yl]amino}acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl{[6-chloro-1-(4-ethoxyphenyl)-4-methoxy-1H-benzimidazol-2-yl]amino}acetate(1623102-50-0)
• EPA Substance Registry System: ethyl{[6-chloro-1-(4-ethoxyphenyl)-4-methoxy-1H-benzimidazol-2-yl]amino}acetate(1623102-50-0)

Safety Data

• Hazardous Substances Data: 1623102-50-0(Hazardous Substances Data)

Upstream product

• 1613081-77-8 C₂₀H₂₂BClF₃N₃O₅ 

Relevant articles and documents

A novel annulation reaction of N-substituted-2-nitrosoanilines with esters of α-isocyano acids. A one-pot, two-step route to 2-benzimidazole- substituted esters of α-amino acids

A BF3-promoted α-addition of isocyanides to both nitrogen atoms of N-aryl-2-nitrosoanilines leads to stable BF3-complexes of 3-N-hydroxy-(2-alkylimino)benzimidazole derivatives, which, after reduction with Zn in AcOH produce 1-N-aryl-2-alkylaminobenzimidazoles. This two-step annulation proceeds efficiently in a one-pot protocol with isocyanides derived from esters of α-amino acids. The chirality of the latter remains unaffected in the reaction.