1623129-72-5Relevant academic research and scientific papers
Discovery of a phenylpyrazole amide ROCK inhibitor as a tool molecule for in vivo studies
Adam, Leonard P.,Cheadle, Nathan L.,Chen, Alice Y.,Chen, Xue-Qing,Glunz, Peter W.,Guarino, Victor R.,HU, ZILUN,Hennan, James,Li, Julia,Myers, Joseph E.,Quan, Mimi L.,Rose, Anne,Sack, John S.,Sitkoff, Doree,Taylor, David S.,Wang, Cailan,Wexler, Ruth R.,Xu, Songmei,Yan, Chunhong,Zhang, Hongwei,Zhang, Lisa
, (2020/08/24)
Structure-activity relationship optimization on a series of phenylpyrazole amides led to the identification of a dual ROCK1 and ROCK2 inhibitor (25) which demonstrated good potency, kinome selectivity and favorable pharmacokinetic profiles. Compound 25 was selected as a tool molecule for in vivo studies including evaluating hemodynamic effects in telemeterized mice, from which moderate decreases in blood pressure were observed.
