16234-40-5

Usage

Uses

Used in Pharmaceutical Research:
4-AMINO-2-CHLOROTHIENO[3,2-D]PYRIMIDINE is used as a building block for the synthesis of biologically active compounds, primarily for its potential in creating anticancer and antiviral agents. Its unique structure allows for the development of new drugs with enhanced efficacy and selectivity.
Used in Material Development:
4-AMINO-2-CHLOROTHIENO[3,2-D]PYRIMIDINE is utilized in the development of new materials, capitalizing on its chemical properties to contribute to the creation of innovative substances with specific applications in various industries.
Used as a Precursor in Organic Synthesis:
4-AMINO-2-CHLOROTHIENO[3,2-D]PYRIMIDINE serves as a precursor in organic synthesis, enabling the production of a range of chemical entities that can be applied across different fields, from pharmaceuticals to chemical manufacturing.
Used in Disease Treatment Research:
4-AMINO-2-CHLOROTHIENO[3,2-D]PYRIMIDINE is under investigation for its potential pharmacological properties, with a focus on its role in the treatment of certain diseases. Its unique structure and functional groups may offer new avenues for therapeutic intervention.

InChI:InChI=1/C6H4ClN3S/c7-6-9-3-1-2-11-4(3)5(8)10-6/h1-2H,(H2,8,9,10)

Upstream product

• 16233-51-5 1H-thieno[3,2-d]pyrimidine-2,4-dione 
• 16234-14-3 2,4-dichlorothieno[3,2-d]pyrimidine 

Relevant academic research and scientific papers

Compound and organic electroluminescent device

The invention provides a compound, which is shown as a following general formula (I) or (II) in the specification, wherein, X is selected from CR 4 or N; R 1 to R 4 are respectively and independentlyselected from hydrogen, C1-C10 alkyl groups, substituted or unsubstituted C5 -C60 aryl or heteroaryl groups, the substituent of aryl or heteroaryl groups is selected from deuterium, fluorine, methyl group, methoxy group, cyano group, phenyl group, biphenyl group, naphthyl group, phenanthryl group, and substituted or unsubstituted anthracyl group, the substituent of the anthracyl group is selectedfrom the group consisting of phenyl, biphenyl, terphenyl, naphthyl, and phenanthryl; and a dotted line and Cy in the general formula (II) represent a five- or six-membered aromatic or heteroaromatic ring fused to a pyrimidine ring. The compound can be used in an organic electroluminescent device. The invention also provides an organic electroluminescent device comprising the above compound.

Antiproliferative activities of halogenated thieno[3,2-d]pyrimidines

The in vitro evaluation of thieno[3,2-d]pyrimidines identified halogenated compounds 1 and 2 with antiproliferative activity against three different cancer cell lines. A structure activity relationship study indicated the necessity of the chlorine at the C4-position for biological activity. The two most active compounds 1 and 2 were found to induce apoptosis in the leukemia L1210 cell line. Additionally, the compounds were screened against a variety of other microbial targets and as a result, selective activity against several fungi was also observed. The synthesis and preliminary biological results are reported herein.