162358-48-7

Basic information

• Product Name: N-[4-(2-hydroxyethyl)phenyl]heptanamide
• Synonyms: N-[4-(2-hydroxyethyl)phenyl]heptanamide
• CAS NO: 162358-48-7
• Molecular Weight: 249.353
• Mol File: 162358-48-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-[4-(2-hydroxyethyl)phenyl]heptanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-(2-hydroxyethyl)phenyl]heptanamide(162358-48-7)
• EPA Substance Registry System: N-[4-(2-hydroxyethyl)phenyl]heptanamide(162358-48-7)

Safety Data

• Hazardous Substances Data: 162358-48-7(Hazardous Substances Data)

Upstream product

• 111-14-8 oenanthic acid 
• 104-10-9 2-(4'-aminophenyl)ethyl alcohol 
• 2528-61-2 Heptanoic acid chloride 

Downstream Products

• 162358-55-6 2-acetylamino-2-{2-[4-(heptyl-methyl-amino)-phenyl]-ethyl}-malonic acid diethyl ester 
• 162358-56-7 acetic acid 2-acetoxymethyl-2-acetylamino-4-[4-(heptyl-methyl-amino)-phenyl]-butyl ester 
• 1027989-08-7 N-{3-[4-(heptyl-methyl-amino)-phenyl]-1,1-bis-hydroxymethyl-propyl}-acetamide 
• 162358-50-1 N-methyl-N-[4-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]phenyl]heptanamide 
• 162358-51-2 heptyl-methyl-{4-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-phenyl}-amine 
• 162358-53-4 methanesulfonic acid 2-[4-(heptyl-methyl-amino)-phenyl]-ethyl ester 
• 162358-54-5 4-(N-methylheptylamino)phenethyl iodide 
• 162358-52-3 4-(N-methylheptylamino)phenethyl alcohol 
• 162358-49-8 N-[4-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]phenyl]heptanamide 

Relevant articles and documents

Synthesis of novel FTY720 analogs with anticancer activity through PP2A activation

FTY720 inhibits various cancers through PP2A activation. The structure of FTY720 is also used as a basic structure for the design of sphingosine kinase (SK) inhibitors. We have synthesized derivatives using an amide chain in FTY720 with a phenyl backbone, and then compounds were screened by an MTT cell viability assay. The PP2A activity of compound 7 was examined. The phosphorylation levels of AKT and ERK, downstream targets of PP2A, in the presence of compound 7, were determined. Compound 7 may exhibit anticancer effects through PP2A activation rather than the mechanism by inhibition of SK1 in cancer cells. In the docking study of compound 7 and PP2A, the amide chain of compound 7 showed an interaction with Asn61 that was different from FTY720, which is expected to affect the activity of the compound.

2-amino-1,3-propanediol compound and immunosuppressant

2-Amino-1,3-propanediol compounds of the formula (I) STR1 wherein R is an optionally substituted straight- or branched carbon chain, an optionally substituted aryl, an optionally substituted cycloalkyl or the like, and R2, R3, R4 and R5 are the same or different and each is a hydrogen, an alkyl, an aralkyl, an acyl or an alkoxycarbonyl, pharmaceutically acceptable salts thereof and immunosuppressants comprising these compounds as active ingredients. The 2-amino-1,3-propanediol compounds of the present invention show immunosuppressive action and are useful for suppressing rejection in organ or bone marrow tranplantation, prevention and treatment of autoimmune diseases or as reagents for use in medicinal and pharmaceutical fields.