16236-44-5Relevant articles and documents
Method for preparing asymmetric terphenyl compound by using brominated aryl sulfuryl fluoride
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Paragraph 0031-0033, (2018/07/30)
The invention discloses a method for preparing asymmetric terphenyl compound by using brominated aryl sulfuryl fluoride, which belongs to the technical field of organic synthetic chemistry. The methodcomprises the following steps: adding brominated aryl sulfuryl fluoride, arylboronic acid, aryl potassium trifluoroborate, a palladium catalyst, inorganic base, ethanol and water in a flask in order,stirring the materials at the temperature of 20-40 DEG C, reacting the materials for 0.5-2 h and adding organic base in the flask, and heating the materials to the temperature of 80-100 DEG C for a continuous reaction for 2-6 h; after a reaction is completed, adding ethyl acetate in the flask, uniformly stirring the materials, transferring a mixture in the flask to a rotary evaporation instrumentfor steaming a solvent, and performing column chromatography separating on a concentrate to obtain the analytically pure asymmetric terphenyl compound. During a whole synthetic method process, an intermediate product is required for being separated, the reaction operation steps can be simplified, ethanol and water are taken as the solvent in the reaction, the environment pollution problem due tothe toxic organic solvent can be solved, the reaction yield is high, and a synthesis approach of the asymmetric terphenyl compound is increased.
