16236-70-7

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 37, p. 3963, 1972 DOI: 10.1021/jo00797a051

InChI:InChI=1/C10H13NO/c1-7-6-10(12)11-9-5-3-2-4-8(7)9/h6H,2-5H2,1H3,(H,11,12)

Upstream product

• 99855-78-4 2-hydroxy-4-methyl-5,6,7,8-tetrahydro-quinoline-3-carboxylic acid 
• 99987-47-0 2-amino-4-methyl-5,6,7,8-tetrahydro-quinoline-3-carboxylic acid amide 
• 874-23-7 2-acetylcyclohexanone 
• 108-94-1 cyclohexanone 
• 141-97-9 ethyl acetoacetate 
• 5977-14-0 acetoacetamido 

Downstream Products

• 878277-66-8 4-methyl-1-(4-nitrophenacyl)-5,6,7,8-tetrahydroquinolin-2-one 
• 764667-25-6 2-methoxy-4-methyl-5,6,7,8-tetrahydroquinoline 
• 904915-43-1 (R)-5,6,7,8-tetrahydro-4-methyl-2-phenylquinolin-8-ol 

Relevant academic research and scientific papers

Rearrangement of 1-Oxa-5-azabicyclo[5.5]undec-2-en-4-ones to 5,6,7,8- Tetrahydroquinolin-2(1H)-ones

Spiro compounds 1 are easily converted into tetrahydroquinolin-2-ones 2 in a one step reaction involving anhydrous strong acidic conditions. A plausible mechanism is discussed.

Ligand-Enabled β-C–H Arylation of α-Amino Acids Without Installing Exogenous Directing Groups

Herein we report acid-directed β-C(sp3)-H arylation of α-amino acids enabled by pyridine-type ligands. This reaction does not require the installation of an exogenous directing group, is scalable, and enables the preparation of Fmoc-protected unnatural amino acids in three steps. The pyridine-type ligands are crucial for the development of this new C(sp3)-H arylation.

PYRIDINE DERIVATIVES AND THEIR USE AS MEDICAMENTS FOR TREATING DISEASES RELATED TO MCH RECEPTOR

The present invention encompasses novel substituted pyridine compounds of Formula (I), which act as MCH receptor antagonists. These compositions and pharmaceutical compositions thereof are useful in the prophylaxis or treatment of improving memory function, sleeping and arousal, anxiety, depression, mood disorders, seizure, obesity, diabetes, appetite and eating disorders, cardiovascular disease, hypertension, dyslipidemia, myocardial infarction, binge eating disorders including bulimia, anorexia, mental disorders including manic depression, schizophrenia, delirium, dementia, stress, cognitive disorders, attention deficit disorder, substance abuse disorders and dyskinesias including Parkinson's disease, epilepsy, and addiction.

Synthesis of Methylpyridine Derivatives. XXXIV. Condensation of Acetoacetamide with Ketones to form Pyridone Derivatives

Condensation of acetoacetamide (1) with acetone in polyphosphoric acid (PPA) gave 4,6-dimethyl-2(1H)-pyridone (2a) in 32percent yield.Similarly, the amide 1 was condensed with 2-butanone, 2-pentanone, 3-pentanone, cyclopentanone, cyclohexanone, cycloheptanone, acetophenone, and propiophenone to give the corresponding pyridone derivatives (2b-i) in 13-76percent yields.Condensation of the amide 1 with acetylacetone and ethyl acetoacetate gave 3-acetyl-4,6-dimethyl-2(1H)-pyridone (5) and ethyl 4,6-dimethyl-2(1H)-pyridone-5-carboxylate (6), respectively.Self-condensation of the amide 1 in PPA gave 3-acetyl-4-hydroxy-6-methyl-2(1H)-pyridone (7).

Anticoccidial complexes of 4,4'-dinitrocarbanilides

Substituted 2- and 4-pyridones, pyrimidin-2- and 6-ones and tetrahydroquinolones when complexed with 4,4'-dinitrocarbanilide provide agents which are active coccidiostats and which produce minimal toxic side effects. Processes for the preparation of these complexes as well as compositions suitable for administration to poultry for the prevention and cure of coccidiosis are also disclosed.