162361-97-9

Upstream product

• 98919-68-7 (1R,2S)-trans-2-phenylcyclohexanol 
• 542-92-7 cyclopenta-1,3-diene 
• 162361-93-5 tert-butyl (1R,2S)-2-phenylcyclohexyl maleate 

Downstream Products

• 162362-01-8 (1R,2S,3R,4S)-Bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid mono-((1R,2S)-2-phenyl-cyclohexyl) ester 
• 162362-02-9 (1R,2S,3R,4S)-3-Hydroxymethyl-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid (1R,2S)-2-phenyl-cyclohexyl ester 

Relevant academic research and scientific papers

Asymmetric Diels-Alder reaction of unsymmetrical maleates. A chemical access to chiral, unsymmetrical cis-cyclohexene-1,2-dicarboxylates

A new route to optically active, unsymmetrical cis-cyclohexene-1,2-dicarboxylate derivatives has been developed on the basis of the asymmetric Diels-Alder reaction of chiral, unsymmetrical maleates catalyzed by certain Lewis acids. A notably high level of asymmetric induction has been observed in the asymmetric Diels-Alder reaction of unsymmetrical maleates possessing chiral auxiliaries such as α-phenethyl and trans-2-phenylcyclohexyl groups. The origin of the chiral outcome using these dienophiles has been elucidated.