162375-26-0

Basic information

• Product Name: 2'-O-(tert-butyldimethylsilyl)-10-deacetylpaclitaxel
• Synonyms: 2'-O-(tert-butyldimethylsilyl)-10-deacetylpaclitaxel
• CAS NO: 162375-26-0
• Molecular Weight: 926.146
• Mol File: 162375-26-0.mol

Chemical Properties

• CAS DataBase Reference: 2'-O-(tert-butyldimethylsilyl)-10-deacetylpaclitaxel(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-O-(tert-butyldimethylsilyl)-10-deacetylpaclitaxel(162375-26-0)
• EPA Substance Registry System: 2'-O-(tert-butyldimethylsilyl)-10-deacetylpaclitaxel(162375-26-0)

Safety Data

• Hazardous Substances Data: 162375-26-0(Hazardous Substances Data)

Upstream product

• 114655-02-6 2'-O-(tert-butyldimethylsilyl)paclitaxel 
• 78432-77-6 10-deacetylpaclitaxel 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 33069-62-4 taxol 

Downstream Products

• 162809-97-4 2'-O-(tert-butyldimethylsilyl)-10-deacetyl-7-O-triethylsilylpaclitaxel 
• 455252-53-6 2'-O-(tert-butyldimethylsilyl)-7-chloroacetyl-10-deacetylpaclitaxel 
• 1051405-78-7 C₃₉H₄₆O₁₂ 
• 1051405-72-1 C₄₇H₅₃NO₁₄ 
• 1051405-75-4 C₅₅H₅₉NO₁₅ 
• 1052091-65-2 C₆₂H₇₁NO₁₇ 
• 849213-05-4 2-O-TES-7-O-methylthiomethyl-9-α-OH-10-epi-paclitaxel 
• 849213-04-3 2'-O-TES-9-α-OH-10-epi-paclitaxel 
• 849213-07-6 C₅₄H₆₇NO₁₄Si 
• 849213-06-5 7-O-methylthiomethyl-9-α-OH-10-epi-paclitaxel 

Relevant articles and documents

Synthesis and cytotoxicity of 7,9-O-linked macrocyclic C-Seco taxoids

A series of novel 7,9-O-linked macrocyclic taxoids together with modification at the C2 position were synthesized, and their cytotoxicities against drug-sensitive and P-glycoprotein and βIII-tubulin overexpressed drug-resistant cancer cell lines were eval

THIOLATED PACLITAXELS FOR REACTION WITH GOLD NANOPARTICLES AS DRUG DELIVERY AGENTS

Thioloated taxane derivatives are linked to colloidal metal particles such as gold nanoparticles for use as antitumor agents. The antitumor agents may be targeted to tumors.

TAXANE ANALOGS FOR THE TREATMENT OF BRAIN CANCER

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Biologically Active Taxane Analogs and Methods of Treatment

The present application relates to new taxane analogs, pharmaceutical compositions comprising such analogs and methods of treating cancer comprising such compositions. The compounds according to the present application have the general formula: wherein R

BIOLOGICALLY ACTIVE TAXANE ANALOGS AND METHODS OF TREATMENT BY ORAL ADMINISTRATION

The present invention relates to a novel chemical compound of formula S-(I) for use in the treatment of cancer, to compositions containing said compound, methods of manufacture and combinations with other therapeutic agents.

Synthesis of 7- and 10-spermine conjugates of paclitaxel and 10-deacetyl-paclitaxel as potential prodrugs

Efficient syntheses of two taxol analogs bearing the linear polyamine spermine at 7- and 10-positions of paclitaxel and 10-deacetyl-paclitaxel have been developed. These polyamine-taxol-conjugates were isolated as water soluble difluoride salts. The aim o

9,10-alpha,alpha-OH-TAXANE ANALOGS AND METHODS FOR PRODUCTION THEREOF

The present invention relates to new taxane analogs useful for the treatment of cancer as well as methods for producing the same. The chemical compounds according to the present invention have the general Formula (I) wherein R1 and R2 are each selected fr

Design, Synthesis, and Bioactivities of Steroid-Linked Taxol Analogues as Potential Targeted Drugs for Prostate and Breast Cancer

The female steroid hormone 3,17β-estradiol (2) was selected as an agent to target taxol (1) to estrogen receptor (ER) positive breast cancer cells. Estradiol-taxol conjugates (ETC) were synthesized through linkages from the 11- or 16-position of estradiol

Synthesis and biological activity of macrocyclic taxane analogues

A series of paclitaxel analogues possessing a macrocyclic structure between the 7 and 10 positions has been prepared. These compounds possess in vitro activity against a paclitaxel resistant cell line and have in vivo activity comparable to paclitaxel.

The chemistry of the taxane diterpene: Stereoselective reductions of taxanes

Stereoselective reductions of taxanes are detailed. Chelation- controlled reductions employing SmI2 are described for the stereoselective reduction of the 9-keto functionality of the diterpene moiety of several taxanes. In all cases the 9β-hydr