1623751-78-9

Upstream product

• 1623752-21-5 5-((tert-butyldimethylsilyl)oxy)-1-(p-tolyl)pent-2-en-1-one 
• 1777-53-3 1-(p-tolyl)-2-(triphenylphosphoranylidene)ethanone 
• 1647059-07-1 C₁₈H₂₆N₂O₂Si 
• 1623751-77-8 (E)-2-diazo-5-hydroxy-1-(ptolyl)pent-3-en-1-one 
• 109-97-7 pyrrole 
• 1616777-23-1 (E)-4-diazo-5-oxo-5-(p-tolyl)pent-2-enal 
• 96631-87-7 1H-indole-7-carbonitrile 
• 5720-05-8 4-methylphenylboronic acid 

Relevant academic research and scientific papers

Synthetic method for drug intermediate aromatic formyl indole derivative

The invention provides a synthetic method for an aromatic formyl indole derivative shown in the formula (I). The formula is defined in the description. The synthetic method includes the steps that inthe presence of an acid-binding agent, an indole compoun

Rhodium enalcarbenoids: Direct synthesis of indoles by rhodium(II)- catalyzed [4+2] benzannulation of pyrroles

Disclosed herein is the design of an unprecedented electrophilic rhodium enalcarbenoid which results from rhodium(II)-catalyzed decomposition of a new class of enaldiazo compounds. The synthetic utility of these enalcarbenoids has been successfully demonstrated in the first transition-metal-catalyzed [4+2] benzannulation of pyrroles, thus leading to substituted indoles. The new benzannulation has been applied to the efficient synthesis of the natural product leiocarpone as well as a potent adipocyte fatty-acid binding protein inhibitor. Fat cat: A new class of enaldiazo compounds resulted in the first transition-metal-catalyzed [4+2] benzannulation of pyrroles to deliver indoles. The benzannulation is proposed to involve an unprecedented diacceptor rhodium enalcarbenoid. The reaction was used in the highly efficient synthesis of the natural product leiocarpone and a potent adipocyte fatty-acid binding protein inhibitor.