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CAS

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1623784-77-9

(E)-1-(4-biphenyl)-3-(1-methoxynaphthalen-2-yl)prop-2-en-1-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1623784-77-9 Structure

  • Basic information

    1. Product Name: (E)-1-(4-biphenyl)-3-(1-methoxynaphthalen-2-yl)prop-2-en-1-one
    2. Synonyms: (E)-1-(4-biphenyl)-3-(1-methoxynaphthalen-2-yl)prop-2-en-1-one
    3. CAS NO:1623784-77-9
    4. Molecular Formula:
    5. Molecular Weight: 364.444
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1623784-77-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (E)-1-(4-biphenyl)-3-(1-methoxynaphthalen-2-yl)prop-2-en-1-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: (E)-1-(4-biphenyl)-3-(1-methoxynaphthalen-2-yl)prop-2-en-1-one(1623784-77-9)
    11. EPA Substance Registry System: (E)-1-(4-biphenyl)-3-(1-methoxynaphthalen-2-yl)prop-2-en-1-one(1623784-77-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1623784-77-9(Hazardous Substances Data)

1623784-77-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1623784-77-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,2,3,7,8 and 4 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1623784-77:
(9*1)+(8*6)+(7*2)+(6*3)+(5*7)+(4*8)+(3*4)+(2*7)+(1*7)=189
189 % 10 = 9
So 1623784-77-9 is a valid CAS Registry Number.

1623784-77-9Downstream Products

1623784-77-9Relevant articles and documents

Design, synthesis, and biological evaluation of 1,3-diarylpropenones as dual inhibitors of HIV-1 reverse transcriptase

Meleddu, Rita,Cannas, Valeria,Distinto, Simona,Sarais, Giorgia,Del Vecchio, Claudia,Esposito, Francesca,Bianco, Giulia,Corona, Angela,Cottiglia, Filippo,Alcaro, Stefano,Parolin, Cristina,Artese, Anna,Scalise, Daniela,Fresta, Massimo,Arridu, Antonella,Ortuso, Francesco,Maccioni, Elias,Tramontano, Enzo

supporting information, p. 1869 - 1879 (2014/08/18)

A small library of 1,3-diarylpropenones was designed and synthesized as dual inhibitors of both HIV-1 reverse transcriptase (RT) DNA polymerase (DP) and ribonuclease H (RNase H) associated functions. Compounds were assayed on these enzyme activities, which highlighted dual inhibition properties in the low-micromolar range. Interestingly, mutations in the non-nucleoside RT inhibitor binding pocket strongly affected RNase H inhibition by the propenone derivatives without decreasing their capacity to inhibit DP activity, which suggests long-range RT structural effects. Biochemical and computational studies indicated that the propenone derivatives bind two different interdependent allosteric pockets.

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