162401-30-1 Usage
Description
N-(3,5-Dichloro-4-pyridinyl)-3,4-bis(difluoroMethoxy)benzaMide, also known as 3,4-Bis(difluoromethoxy) Roflumilast, is a chemical compound derived from Roflumilast, an anti-asthmatic drug. It is characterized by its unique molecular structure, which includes a 3,5-dichloro-4-pyridinyl group and two difluoromethoxy groups attached to a benzamido scaffold. N-(3,5-Dichloro-4-pyridinyl)-3,4-bis(difluoroMethoxy)benzaMide is an impurity found in the production process of Roflumilast, which is used for the treatment of chronic obstructive pulmonary disease (COPD) and asthma.
Uses
Used in Pharmaceutical Industry:
N-(3,5-Dichloro-4-pyridinyl)-3,4-bis(difluoroMethoxy)benzaMide is used as an impurity in the production of the anti-asthmatic drug Roflumilast (R639700) for the treatment of chronic obstructive pulmonary disease (COPD) and asthma. Its presence in the drug manufacturing process is crucial for quality control and ensuring the safety and efficacy of the final product.
In the pharmaceutical industry, the identification and control of impurities like 3,4-Bis(difluoromethoxy) Roflumilast are essential to maintain the desired therapeutic effects of the drug and minimize any potential adverse effects. N-(3,5-Dichloro-4-pyridinyl)-3,4-bis(difluoroMethoxy)benzaMide serves as a case study for the importance of impurity profiling and management in drug development and production.
Check Digit Verification of cas no
The CAS Registry Mumber 162401-30-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,2,4,0 and 1 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 162401-30:
(8*1)+(7*6)+(6*2)+(5*4)+(4*0)+(3*1)+(2*3)+(1*0)=91
91 % 10 = 1
So 162401-30-1 is a valid CAS Registry Number.
162401-30-1Relevant articles and documents
Production and preparation method of roflumilast crystalline powder bulk drug
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Paragraph 0016-0017, (2021/03/06)
The invention discloses a production and preparation method of a roflumilast crystalline powder bulk drug. The method comprises the following steps of: 1) acylation reaction: dropwise adding thionyl chloride into a toluene solution of 3-cyclopropylmethoxy-4-difluoromethoxybenzoic acid, and heating the reaction mixture to reflux, carrying out reaction for 2h, then conducting reduced pressure concentration to remove the solvent, dissolving the residue left by concentration in tetrahydrofuran, controlling the temperature of the solution at 15-20DEG C under stirring and dropwise adding the solution into a tetrahydrofuran solution of 4-amino-3, 5-dichloropyridine and sodium hydride; and 2) refining. The method has the beneficial effects that: a commercially available starting material of 1 (3-cyclopropylmethoxy-4-difluoromethoxybenzoic acid) and a starting material of 2 (4-amino-3, 5-dichloropyridine) are selected as the starting materials, acylation and refining are carried out to obtain roflumilast, the process is stable, the yield is high, and industrial production is easy.
