1624290-40-9Relevant academic research and scientific papers
Unsymmetrical bisphosphines for the amidation of aryl chlorides: A kinetic study
Falk, Florian C.,Oechsle, Peter,Thiel, Werner R.,Daniliuc, Constantin-Gabriel,Paradies, Jan
supporting information, p. 3637 - 3645 (2014/06/23)
The rate-determining step of the palladium-catalyzed amidation of 4-chlorotoluene with benzamide in the presence of unsymmetrical bisphosphines was investigated. Isostructural [2.2]paracyclophane-derived bisphosphines bearing dicyclohexylphosphino and diarylphosphino moieties were investigated as ligands in the oxidative addition and reductive elimination by kinetic studies. The reductive elimination was accelerated when a bisphosphine ligand was applied that contained an electron-rich phosphine group and a less electron-releasing phosphino moiety. Apart from the reductive elimination, the transmetallation had the largest impact on the palladium-catalyzed amidation of aryl halides. Copyright
