162458-73-3

Upstream product

• 77-76-9 2,2-dimethoxy-propane 
• 162458-76-6 [(R)-1-(3-Bromo-4-hydroxy-phenyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester 
• 162458-72-2 methyl (2R)-2-(3-bromo-4-hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate 
• 162458-71-1 methyl (2R)-2-amino-2-(3-bromo-4-hydroxyphenyl)acetate 
• 139517-61-6 (R)-3-bromo-4-hydroxyphenylglycine 
• 22818-40-2 D-4-hydroxyphenylglycine 

Downstream Products

• 229154-35-2 4-{4-[3-benzyloxy-1-benzyloxymethyl-2-(tert-butyl-dimethyl-silanyloxy)-propoxy]-3-bromo-phenyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 229154-37-4 (R)-4-[4-((1R,2S)-3-Benzyloxy-1-benzyloxymethyl-2-hydroxy-propoxy)-3-bromo-phenyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 162458-74-4 (R)-4-(3-Bromo-4-methoxy-phenyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

An intramolecular, Ni(0)-mediated approach to the nonracemic biaryl portion of vancomycin

Using a tether derived from tartaric acid to which is attached two halogenated phenylglycine residues, a Ni(0)-induced biaryl coupling can be effected with complete control of axial chirality.

A concise route to biaryls: Formal synthesis of biaryl diamino diacid (AB segment) of vancomycin

An efficient approach to the AB segment of vancomycin involving triphenylphosphine-catalysed coupling of the substituted aryl lithio compound (13) with palladium complex (14) of aromatic Schiff base derived from 3,5- dimethoxybenzaldehyde is described.