1624580-34-2Relevant academic research and scientific papers
Derivatives of salarin A, salarin C and tulearin A - Fascaplysinopsis sp. metabolites
Zur, Lee Goren,Bishara, Ashgan,Aknin, Maurice,Neumann, Drorit,Ben-Califa, Nathalie,Kashman, Yoel
, p. 4487 - 4509 (2013)
Derivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenous macrolides, were prepared and bio-evaluated as inhibitors of K562 leukemia cells. Interesting preliminary SAR (structure activity relationship) information was obtained from the products. The most sensitive functionalities were the 16,17-vinyl epoxide in both salarins, the triacylamino group in salarin A and the oxazole in salarin C (less sensitive). Regioselectivity of reactions was also found for tulearin A.
