162471-99-0Relevant academic research and scientific papers
Synthesis and biological activity of new 3-hydroxy-3-methylglutaryl-CoA synthase inhibitors: 3-Oxetanones with a side chain mimicking the extended structure of 1233A
Hashizume,Ito,Morikawa,Kanaya,Nagashima,Usui,Tomoda,Sunazuka,Kumagai,Omura
, p. 2097 - 2107 (2007/10/02)
Structural analogs of 1233A, a microbial metabolite inhibiting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase, were designed and synthesized. The 2-oxetanone moiety was left intact. All analogs prepared were tested for inhibition of HMG-CoA synt
