162479-06-3Relevant academic research and scientific papers
Enantiotopos-selective C-H oxygenation catalyzed by a supramolecular ruthenium complex
Frost, James R.,Huber, Stefan M.,Breitenlechner, Stefan,Bannwarth, Christoph,Bach, Thorsten
, p. 691 - 695 (2015)
Spirocyclic oxindoles undergo an enantioselective oxygenation reaction (nine examples; e.r. up to 97:3) upon catalysis by a chiral ruthenium porphyrin complex (1 mol%). The catalyst exhibits a lactam ring, which is responsible for substrate association through hydrogen bonds, and an active ruthenium center, which is in a defined spatial relationship to the oxygenation substrate. DFT calculations illustrate the perfect alignment of the active site with the reactive C-H bond and suggest-in line with the kinetic isotope effect-an oxygen rebound mechanism for the reaction.
METHODS AND COMPOSITIONS COMPRISING MACROCYCLES
-
Page/Page column 11, (2011/06/26)
The present invention relates generally to methods and compositions comprising macrocycles. In some embodiments, the present invention provides methods for modifying macrocycles comprising a pendant group. In some cases, the pendent group comprises a hydrolyzable group. The present invention also provides methods for metallating a macrocycle using microwave energy, in some embodiments.
Efficient synthesis of hangman porphyrins
Dogutan, Dilek K.,Kwabena Bediako,Teets, Thomas S.,Schwalbe, Matthias,Nocera, Daniel G.
supporting information; experimental part, p. 1036 - 1039 (2010/06/15)
Chemical equation presented A two-step synthetic method has been designed to furnish hangman porphyrins In good yields from easily available starting materials. The use of the microwave Irradiation technique has been found to be valuable for delivering the car boxy lie acid hanging group in a much simplified and less time-consuming basic ester hydrolysis (4 h vs 7 days under harsh acidic conditions). The new route facilitates the synthesis of various hangman porphyrins that previously had limited or no access.
