1624848-64-1Relevant articles and documents
Binding to large enzyme pockets: Small-molecule inhibitors of trypanothione reductase
Persch, Elke,Bryson, Steve,Todoroff, Nickolay K.,Eberle, Christian,Thelemann, Jonas,Dirdjaja, Natalie,Kaiser, Marcel,Weber, Maria,Derbani, Hassan,Brun, Reto,Schneider, Gisbert,Pai, Emil F.,Krauth-Siegel, R. Luise,Diederich, Fran?ois
, p. 1880 - 1891 (2014/08/18)
The causative agents of the parasitic disease human African trypanosomiasis belong to the family of trypanosomatids. These parasitic protozoa exhibit a unique thiol redox metabolism that is based on the flavoenzyme trypanothione reductase (TR). TR was ide