162504-86-1Relevant articles and documents
4 - piperidinyl - 1H - pyrrole - 3 - carboxamides hydrochloride synthetic method
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, (2017/08/25)
The invention discloses a synthesis method of 4-piperidyl-1H-pyrrole-3-formamide compound hydrochloride. The method comprises the following steps: reacting a compound I Boc-4-hydroxymethyl piperidine with oxalyl chloride to obtain a compound II, and reacting the compound II with triethyl phosphonoacetate to obtain a compound III; reacting the compound III with p-toluenesulfonylmethyl isocyanide to obtain a compound IV; reacting the compound IV with 2-(trimethylsilyl)-ethoxymethyl chloride to generate a compound V; hydrolyzing the compound V to obtain a compound VI, and reacting the compound VI with an amino compound to generate a compound VII; acting on the compound VII with tetrabutylammonium fluoride to generate a compound VIII; and acting on the compound VIII with HCI to generates a compound IX, namely 4-piperidyl-1H-pyrrole-3-formamide compound hydrochloride. According to the method, piperidyl and acylamino are introduced at the positions 3 and 4 on a pyrrole ring, the reaction route is simple and feasible, and the obtained compound has a plurality of reactive groups and good water solubility and has potentials for development of medical intermediates.
PIPERIDINYL COMPOUNDS THAT SELECTIVELY BIND INTEGRINS
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Page 83, (2010/11/30)
The invention is directed to piperidinyl compounds of formula (I) and (II) that selectively bind integrin receptors and methods for treating an integrin mediated disorder, wherein W, R2, Z and q are described in the application.