162515-56-2Relevant articles and documents
PENAM DERIVATIVES
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, (2008/06/13)
The present invention discloses compounds having the formula wherein one of R1 and R2 is ?COR4, ?CN, ?CH2R5. halogen. ?CH=CHR6 or Q and the other is hydrogen or lower alkyl or both R1 and R2 together form a gamma-lactam ring, R3 is hydrogen, lower alkyl. aryl-alkyl, allyl or a residue which is cleavable in vivo, R4 is hydrogen, lower alkyl, lower alkoxy. benzyloxy, amino, lower alkylamino or lower alkyl-lower alkoxyamino. R5 is hydroxy. ?OCONHR7. ?OCONH2 or a five- or six-membered hetero-aromatic ring which contains N,S and/or O and which is linked via a nitrogen atom, R6 is ?CN or CHO. R7 is ?COCH2Cl. Q is a five- or six-membered hetero-aromatic ring which contains N, S and/or O and n is 0, 1 or 2, and the pharmaceutically compatible salts thereof. These compounds are good beta-lactamase inhibitors. They can be used for the prevention or treatment of bacterial infections, optionally together with a beta-lactam antibiotic