16252-12-3Relevant academic research and scientific papers
Formation of C(sp3)–C(sp3) Bonds through Nickel-Catalyzed Decarboxylative Olefin Hydroalkylation Reactions
Lu, Xi,Xiao, Bin,Liu, Lei,Fu, Yao
, p. 11161 - 11164 (2016)
Olefins and carboxylic acids are among the most important feedstock compounds. They are commonly found in natural products and drug molecules. We report a new reaction of nickel-catalyzed decarboxylative olefin hydroalkylation, which provides a novel practical strategy for the construction of C(sp3)?C(sp3) bonds. This reaction can tolerate a variety of synthetically relevant functional groups and shows good chemo- and regioselectivity. It enables cross-coupling of complex organic molecules containing olefin groups and carboxylic acid groups in a convergent fashion.
