16252-62-3

Usage

Uses

Used in Medicinal Chemistry:
3-AMINO-1,3-DIAZASPIRO[4.4]NONANE-2,4-DIONE is used as a building block for the development of novel pharmaceutical compounds due to its unique spirocyclic structure and potential for biological activity.
Used in Drug Design:
In the pharmaceutical industry, 3-AMINO-1,3-DIAZASPIRO[4.4]NONANE-2,4-DIONE is utilized as a key intermediate in the synthesis of new drugs, leveraging its chemical properties to create molecules with specific therapeutic effects.

InChI:InChI=1/C7H11N3O2/c8-10-5(11)7(9-6(10)12)3-1-2-4-7/h1-4,8H2,(H,9,12)

Upstream product

• 120-92-3 cyclopentanone 
• 699-51-4 1,3-diazaspiro[4.4]nonane-2,4-dione 

Relevant academic research and scientific papers

Aminoderivatives of cycloalkanespirohydantoins: Synthesis and biological activity

3-Aminocycloalkanespiro-5-hydantoins were synthesized and their biological activity was studied. In contrast to hydantoins, these compounds failed to induce either anticonvulsive effects in the central nervous system or inhibitory effects on cholinergic contractions in the enteric nervous system. However, they exerted well pronounced, atropinsensitive, contractile effects on the guinea-pig ileum longitudinal muscle preparations. Structure-activity relationships established allow the assumption that: (i) the reduction of the ring size in the molecule of the spirohydantoins leads to an increase in the potency of the respective analogue to induce contractile effect; (ii) the introduction of -NH2 in position 3 increases the ability of all the compounds studied to exert contractions; (iii) the enlargement of the ring leads to: (1) an increase of the degree of desensitization of the preparations; and (2) a decrease (except 1a) of the potency of the analogues to exert contractile effects.