16252-93-0

Basic information

• Product Name: 3-AMINO-8-METHYL-1,3-DIAZASPIRO[4.5]DECANE-2,4-DIONE
• Synonyms: 1,3-diazaspiro[4.5]decane-2,4-dione, 3-amino-8-methyl-; 3-Amino-8-methyl-1,3-diazaspiro[4.5]decane-2,4-dione
• CAS NO: 16252-93-0
• Molecular Formula: C9H15N3O2
• Molecular Weight: 197.23
• Mol File: 16252-93-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.28g/cm³
• Refractive Index: 1.579
• PKA: 9.78±0.40(Predicted)
• CAS DataBase Reference: 3-AMINO-8-METHYL-1,3-DIAZASPIRO[4.5]DECANE-2,4-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-8-METHYL-1,3-DIAZASPIRO[4.5]DECANE-2,4-DIONE(16252-93-0)
• EPA Substance Registry System: 3-AMINO-8-METHYL-1,3-DIAZASPIRO[4.5]DECANE-2,4-DIONE(16252-93-0)

Safety Data

• Hazardous Substances Data: 16252-93-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H15N3O2/c1-6-2-4-9(5-3-6)7(13)12(10)8(14)11-9/h6H,2-5,10H2,1H3,(H,11,14)

Upstream product

• 88809-35-2 8-methyl-1,3-diazaspiro[4.5]decane-2,4-dione 
• 589-92-4 1-methylcyclohexan-4-one 

Relevant articles and documents

Synthesis, characterization and antimicrobial activity of nalidixic acid derivatives with spirohydantoins

This article presents the synthesis of a series of amides, based on the interaction of several 3-aminospirohydantoins with nalidixic acid. The target compounds were characterized by physicochemical parameters, IR, 1H and 13C NMR spectral data. The antimicrobial activity of the products obtained was determined against Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis, Gram-negative bacteria Escherichia coli, Pseudomonas aeruginosa and Salmonella abony, the yeasts Candida albicans and Saccharomyces cerevisiae and the molds Penicillium chrysogenum and Aspergillus niger. The relationship between structure and biological activity of the products obtained was discussed. It was found that the most effective compounds are tetralin (5f) and indane (5g) derivatives, which exhibit a pronounced antimicrobial activity against both tested Gram-positive and Gram-negative bacteria.