162612-08-0

Usage

Uses

Used in Coordination Chemistry:
2,2'-Bipyridine, 5-chlorois used as a ligand for forming stable complexes with various metal ions. The addition of the chlorine atom alters its electronic and steric properties, making it suitable for specific applications in coordination chemistry.
Used in Catalysis:
2,2'-Bipyridine, 5-chlorois used as a catalyst in various chemical reactions. Its unique properties make it a valuable building block for the synthesis of complex organic molecules and coordination complexes, enhancing the efficiency and selectivity of catalytic processes.
Used in Organic Synthesis:
2,2'-Bipyridine, 5-chlorois used as a reagent or intermediate in the synthesis of complex organic molecules. Its unique electronic and steric properties make it suitable for specific applications in organic synthesis, contributing to the development of novel organic compounds.
Used in Material Science:
2,2'-Bipyridine, 5-chlorois used in the development of new materials with specific properties. Its ability to form stable complexes with metal ions makes it a valuable component in the design and synthesis of advanced materials for various applications in material science.

Upstream product

• 26437-49-0 tris(2-pyridyl)phosphine oxide 
• 1122-62-9 2-acetylpyridine 
• 40473-01-6 2-Bromo-5-chloro-pyridine 
• 162612-11-5 tris(2-pyridyl)phosphine dichloride 
• 26437-48-9 tris(2-pyridyl)phosphine 

Relevant academic research and scientific papers

Copper-Free One-Pot Sonogashira-Type Coupling for the Efficient Preparation of Symmetric Diarylalkyne Ligands for Metal-Organic Cages**

The often time-consuming and challenging multi-step synthesis of ligands for metal-organic cages is a limiting factor for the discovery and application of new cages. We report a highly efficient copper-free one-pot Sonogashira-type coupling for the preparation of symmetric diarylalkyne ligands on both a small and large scale; bipyridine- and benzimidazole-based ligands for the self-assembly of Co4L6 cages were synthesized in short reaction times and high isolated yields directly from aryl halide precursors. This one-pot method reduces the synthetic burden of ligand synthesis and will facilitate the preparation of ligands with additional functionality for applications of their corresponding cages.

A general preparation of pyridines and pyridones via the annulation of ketones and esters

A general preparation of pyridines 4a-f from stabilized ketones 3a-c and aryl ketones 3d-f is described. The annulation of stabilized esters 3g,h gives access to the corresponding 2-pyridones 4g,h. The annulation reactions proceed in fair to excellent yie

Unusual formation of 5-halo-2,2'-bipyridyls by treatment of tris(2-pyridyl)phosphine derivatives with halogens

Reaction of tris(2-pyridyl)phosphine with chlorine in dichloromethane or acetonitrile gave chlorotris(2-pyridyl)phosphonium chloride which afforded a coupling product, 2,2'-bipyridyl, by treating with dilute HCl. Treatment of tris(2-pyridyl)phosphine or tris(2-pyridyl)phosphine oxide with chlorine or bromine in methanol gave unusual 5-halo-2,2'-bipyridyl as a major coupling product. This is undoubtedly an electrophilic substitution on a pyridyl ring in the pentacovalent phosphorane.