162654-95-7Relevant articles and documents
The synthesis of natural R-(-)enantiomers from three galbanum resin macrolides
Bestmann,Kellermann
, p. 1257 - 1261 (2007/10/02)
The three macrolides 1, 2 and 3 isolated from galbanum resin were synthesized starting from ω-bromoacetals 9. The key step is the buffered intramolecular Wittig reaction of the ylides 14 and 23 to afford the α,β-unsaturated lactones 15, 16 and 24. Hydrogenation of these lactones gives the title macrolides in (R)-configuration.
