162679-89-2

Upstream product

• 123311-17-1 N-(benzyloxycarbonyl)-(E)-2,3-methanoleucine p-nitrobenzyl ester 
• 123311-16-0 N-(benzyloxycarbonyl)-(Z)-2,3-methanoleucine p-nitrobenzyl ester 
• 161793-90-4 6-tert-butoxycarbonyl-(Z)-5-isobutylidene-(7aS)-3a,6-diazaperhydroindane-4,7-dione 
• 114673-62-0 (S)-3-[(Z)-isobutylidene]hexahydropyrrolo[1,2-a]pyrazine-1,4-dione 
• 161793-92-6 6-tert-butoxycarbonyl-(7aS)-3a,6-diazaperhydroindane-4,7-dione-5-spiro-3'-<(3'S,4'S)-4'-iso-propyl-1'-pyrazoline> 
• 161793-95-9 6-tert-butoxycarbonyl-(7aS)-3a,6-diazaperhydroindane-4,7-dione-5-spiro-1'-<(1'S,2'S)-2'-iso-propylcyclopropane> 
• 123311-14-8 p-nitrobenzyl 3-<(benzyloxycarbonyl)amino>-5-isopropyl-1-pyrazoline-3-carboxylate 

Relevant academic research and scientific papers

Asymmetric syntheses of 1-amino-2-phenyl(alkyl)cyclopropanecarboxylic acids by diastereoselective cyclopropanation of highly functionalized monochiral olefines

Monochiral α-benzamidocinnamic esters of N-methylephedrine or mandelic derivatives and benzylidene or alkylidene diketopiperazines, all obtained from oxazolones, react with diazomethane to give moderate to high diastereomeric excesses (d.e.) of pyrazoline

1-Aminocyclopropane-1-carboxylic acid derivatives: A new, general synthesis and NMDA receptor complex binding affinity study

A new synthesis of 1-aminocyclopropane-1-carboxylic acid and of its (E)- and (Z)-2-substituted analogues (R = CH3;i-Pr;C6H5) has been performed by means of the 'diazo-addition' method, starting from N-(diphenylmethylene)-2,3-dehydro-1-amino-1-carboxylate precursors. The (E)- and (Z)-2-phenyl and the (Z)-2-methylcyclopropaneamino acids have been obtained with high diastereospecificity. All the cyclopropaneamino acids prepared were tested for their affinity for some glutamate receptors and resulted inactive, wich the exception of compounds (E)-1b and (Z)-1c which showed a shallow displacement of [H]-glycine binding.