162693-99-4

Upstream product

• 2231-57-4 Thiocarbohydrazide 
• 162901-49-7 N-(4-methylphenyl)-N-ethoxycarbonyl-β-alanine 
• 27418-59-3 3-(p-methylphenylamino)propanoic acid 
• 162693-70-1 5-[2-[(4-methylphenyl)amino]ethyl]-1,3,4-oxadiazol-2(3H)-thione 

Relevant academic research and scientific papers

The synthesis of azole derivatives from 3-[(4-methylphenyl)amino]- propanehydrazide and its N'-phenylcarbamoyl derivatives, and their antibacterial activity

5-[2-[(4-Methylphenyl)amino]ethyl]-1,3,4-oxadiazol- 2(3H)-thione, 5-[2-[(4-methylphenyl)amino]ethyl]- 1,3,4-oxadiazol-2(3H)-one, N-(2,5-dimethyl-1H-pyrrol-1-yl)- 3-[(4-methylphenyl)amino]propanamide, and a series of N-[(phenylcarbamoyl)amino]-3-[(4-methylphenyl)amino]- propanamides and 3-[(4-methylphenyl)(phenylcarbamoyl)- amino]-N-[(phenylcarbamoyl)amino] propanamides, and their thio analogues were synthesized from 3-[(4-methylphenyl)- amino]propanehydrazide. 1,3,4-Oxadiazole-2(3H)-thione was converted to 4-amino-2,4-dihydro-5-[2-[(4-methylphenyl)- amino]ethyl]-3H-1,2,4- triazole-3-thione, whereas cyclization of N'-phenylcarbamoyl derivatives provided thiazole, oxadiazoles, and thiadiazole, as well as triazole derivatives. Two of the synthesized compounds exhibited good antibacterial activity against Rhizobium radiobacter. Springer-Verlag 2012.

Preparation of aminotriazole- thione derivatives from N-aryl- N-carboxyethyl-β-alanines

Depending on the substituents in the aryl moiety, the fusion of N-aryl-N-ethoxycarbonyl-β-alanines with thiocarbohydrazide gives di- or monotriazole derivatives, namely, 4-amino-(2-{[2-(4-amino-5-thioxo-4, 5-dihydro-1H-1, 2, 4-triazol-3-yl)ethyl]anilino}e