1627-18-5Relevant academic research and scientific papers
Synthesis of benzofuran scaffold-based potential PTP-1B inhibitors
Dixit, Manish,Tripathi, Brajendra K.,Tamrakar, Akhilesh K.,Srivastava, Arvind K.,Kumar, Brijesh,Goel, Atul
, p. 727 - 734 (2007/10/03)
Protein tyrosine phosphatase 1B (PTP-1B) is an enzyme that plays a critical role in down-regulating insulin signaling through dephosphorylation of the insulin receptor. Studies have shown that PTP-1B knockout mice showed increased insulin sensitivity in m
A controlled synthesis of nature-mimicking benzofurans and their corresponding dimers
Dixit, Manish,Sharon, Ashoke,Maulik, Prakas R.,Goel, Atul
, p. 1497 - 1502 (2007/10/03)
Benzofurans functionalized with hydroxy and acetyl functionalities are not only the core structures found in a large number of biologically important natural products, but also the vital precursors for several naturally occurring furanoflavonoids. Numerou
STUDIES ON QUINONES. VI. ACID CATALIZED REARRANGEMENTS IN SOME 4-ACETYL-2,3-DIHYDROBENZOFURANS
Barrios, Luis,Ruiz, V. Manuel,Tapia, Ricardo,Valderrama, Jaime,Vega, Juan C.
, p. 187 - 190 (2007/10/02)
The reaction of 2-acetyl- and 5-acetyl-2-methoxy-1,4-benzoquinone (1a, 1c) with N-propenylpiperidine gave the corresponding 2,3-dihydrobenzofurans, 2b and 2c, containing the acetyl group at C-4.Acid treatment of these dihydrofurans rearranged to 8-methyl- and 2-methoxy-8-methyljuglone (4a, 4b).Juglone (4c) and 2,3-dihydrojuglone (6) were obtained in fair yields from 4-acetyl-2,5-dihydroxy-2,3-dihydrobenzofuran (2e).
