1627-28-7

Usage

Uses

Used in Medical Research:
6-Chlorothymine is used as a research tool for studying nucleic acids and nucleotides, particularly in the investigation of DNA replication and repair mechanisms. Its ability to inhibit the growth of certain cancer cell lines makes it a potential candidate for anticancer drug development.
Used in Anticancer Drug Development:
6-Chlorothymine is used as a potential anticancer agent, targeting the growth of specific cancer cell lines. Its role in inhibiting cancer cell growth contributes to the development of new therapeutic approaches for cancer treatment.
Used in Epigenetics and Gene Expression Research:
6-Chlorothymine is used as a research compound to investigate the effects of DNA modifications on gene expression and epigenetics. This helps in understanding the complex interactions between genetic and environmental factors in the regulation of gene expression.

InChI:InChI=1/C5H5ClN2O2/c1-2-3(6)7-5(10)8-4(2)9/h1H3,(H2,7,8,9,10)

Upstream product

• 1780-36-5 5-methyl-2,4,6-trichloropyrimidine 
• 2417-22-3 5-methylbarbituric acid 

Downstream Products

• 31458-38-5 6-iodo-5-methylpyrimidine-2,4(1H,3H)-dione 
• 1393847-17-0 6-chloro-1-((4-chlorophenoxy)methyl)thymine 
• 1393847-16-9 6-chloro-1-(2,5-dimethylbenzyl)thymine 
• 1393847-30-7 1-((2-trimethylsilylethoxy)methyl)-6-(3-aminophenylthio)thymine 
• 1393847-31-8 1-((2-trimethylsilylethoxy)methyl)-6-(2,6-dichlorophenylthio)thymine 
• 1393847-32-9 1-((2-trimethylsilylethoxy)methyl)-6-(3-chlorophenylthio)thymine 
• 1393847-33-0 1-ethoxymethyl-6-(3-aminophenylthio)thymine 
• 1393847-34-1 1-ethoxymethyl-6-(2,6-dichlorophenylthio)thymine 
• 1393847-36-3 1-(2,5-dimethylbenzyl)-6-(phenylthio)thymine 
• 1393847-37-4 1-(2,5-dimethylbenzyl)-6-(3-aminophenylthio)thymine 
• 1393847-40-9 1-ethoxymethyl-3,4-dihydro-5-methyl-6-(phenylthio)-4-thioxopyrimidin-2(1H)-one 
• 123027-56-5 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine 
• 132774-39-1 1-(ethoxymethyl)-6-(phenylthio)thymine 
• 661486-62-0 4-(4-chloro-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-ylmethyl)-benzoic acid tert-butyl ester 

Relevant academic research and scientific papers

IMAGING AGENTS

The present invention relates to radiolabelled 4-(furo[3,2-c]pyridin-4-yl) derivatives and their use as radioactive tracers, and in particular their use as imaging agents.

Diverse combinatorial design, synthesis and in vitro evaluation of new HEPT analogues as potential non-nucleoside HIV-1 reverse transcription inhibitors

New analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) were synthesized and evaluated for their in vitro activities against HIV-1 in MT-4 cell cultures. Chemical diversity was introduced in 4 of the six positions of the core and the influence of each substituent was studied. This library was built on the basis of a rational diversity analysis with the objective of maximizing diversity and thus, the activity range with a minimum number of synthesized compounds. Among them, 2{1,2,3,1} and 2{1,2,3,4} exhibited the most potent anti-HIV-1 activities (EC50 = 0.015 μg/mL; 0.046 μM, SI >1667) and (EC50 = 0.025 μg/mL; 0.086 μM, SI >1000), respectively, which were about 71-fold and 38-fold more active than the reference compound HEPT (EC50 = 1.01 μg/mL; 3.27 μM, SI >25).

Functionalization of unprotected uracil derivatives using the halogen - Magnesium exchange

The reaction of commercially available 5-iodouracil with 2 equiv of MeMgCl in the presence of LiCl, followed by the addition of i-PrMgCl-LiCl, provides the corresponding trimagnesiated species, which reacts with various electrophiles to give selectively 5