162750-10-9 Usage
Chemical class
Hydroxyureas
Structure
Dihydrobenzofuran ring
Hydroxyurea functional group
Stereochemistry
(3S) configuration
Fluorination
2,6-difluorobenzyl group attached to the dihydrobenzofuran ring
Biological activity
Potential to modulate biological processes
May act as an inhibitor of certain enzymes or receptors
Pharmaceutical applications
Candidate for drug development
Possible treatment of various diseases
Research status
Further research needed to fully understand potential uses and biological effects
These properties and contents are based on the information provided in the material, which describes the chemical as a synthetic compound with a complex structure and potential pharmaceutical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 162750-10-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,2,7,5 and 0 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 162750-10:
(8*1)+(7*6)+(6*2)+(5*7)+(4*5)+(3*0)+(2*1)+(1*0)=119
119 % 10 = 9
So 162750-10-9 is a valid CAS Registry Number.
162750-10-9Relevant articles and documents
Enantioselective Synthesis of 5-LO Inhibitor Hydroxyureas. Tandem Nucleophilic Addition-Intramolecular Cyclization of Chiral Nitrones
Lantos, Ivan,Flisak, Joseph,Liu, Li,Matsuoka, Richard,Mendelson, Wilf,Stevenson, David,Tubman, Ken,Tucker, Lynn,Zhang, Wei-Yuan,Adams, Jerry,Sorenson, Margaret,Garigipati, Ravi,Erhardt, Karl,Ross, Steve
, p. 5385 - 5391 (1997)
An enantioselective synthesis of chiral hydroxyurea based 5-lipoxygenase inhibitors is reported via a five-step sequence in about 30% overall yield. The synthesis is based on a novel tandem nucleophilic addition-intramolecular cyclization reaction in which a chiral nitrone functions as the electrophilic acceptor species. A mannose-based chiral auxiliary controls the diastereoselectivity of the reaction in an 8:1 ratio. After the auxiliary removal and appropriate functionalization, a single recrystallization afforded the target structures in >99% ee.
