1627898-10-5Relevant articles and documents
Cleavage of 2-(Arylamino)-4,6-dimethoxypyrimidines to yield arylguanidines
Shaw, Julian W.,Grayson, David H.,Rozas, Isabel
, p. 3565 - 3569 (2014)
A novel method for the synthesis of aryl-substituted guanidines in good overall yields is presented; it consists of the acidic cleavage of 2-(arylamino)-4,6-dimethoxypyrimidines, which were prepared by coupling aryl bromides with 2-amino-4,6-dimethoxypyrimidine. This methodology introduces a new means of protection for the guanidine functionality. Copyright