1627941-48-3Relevant academic research and scientific papers
Diarylamines incorporating hexahydrophenalene or octahydrobenzoheptalene as Retinoid X Receptor (RXR)-specific agonists
Amano, Yohei,Noguchi, Masayuki,Shudo, Koichi
, p. 254 - 259 (2014/04/17)
Selective ligands for retinoic acid receptors (RARs) and for retinoid X receptors (RXRs) are required for both biological studies and therapeutic purposes. We have synthesized a series of diarylamines incorporating hexahydrophenalene or octahydrobenzoheptalene as a hydrophobic moiety and examined their activities towards RARs and RXRs. Most of these compounds showed agonistic activity towards RXRs, but were inactive towards RARs. These RXR-specific ligands showed synergistic activity in RARα,β ligand-induced terminal differentiation of leukemia cell line HL-60.
