1628-59-7Relevant academic research and scientific papers
Ratiometric polymer probe for detection of peroxynitrite and the application for live-cell imaging
Lao, Hio Kuan,Tan, Jingyun,Wang, Chunfei,Zhang, Xuanjun
, (2019)
Peroxynitrite (ONOO?) is one of the sources of oxidation stress involved in many biological signaling pathways. The role of ONOO? being a double-edged sword in biological systems drives the development of effective detection tools. In this work, a boronate-based polymeric fluorescent probe PB-PVA was synthesized and the probe performance was evaluated. The probe exhibits ratiometric sensing of ONOO? in a range of 0–6 μM. There is good linear relationship between the probe fluorescence intensity ratio and ONOO? concentration. The probe also displays moderate selectivity towards ONOO? over other ROS. Moreover, it is water-soluble and possesses good biocompatibility which aids the imaging of ONOO? in living cells. These properties could make the probe a promising tool in in vitro study related to ONOO?
NOVEL COMPOUND FOR IMAGING TAU PROTEIN ACCUMULATED IN THE BRAIN
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Paragraph 0119-0121, (2014/09/02)
The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof. wherein: R1 and R2 are each separately selected from the group consisting of hydrog
Synthesis and study of novel benzothiazole derivatives with potential nonlinear optical properties
Sigmundova, Ivica,Zahradnik, Pavol,Loos, Dusan
, p. 1069 - 1093 (2008/12/22)
The synthesis of new benzothiazole push-pull systems as candidates for NLO-phores is described. Spectral (UV/VIS and solvatochromic) and theoretical studies (electronic properties based on semiempirical AM1 and PM3 methods) of the prepared compounds were carried out. The structure and physico-chemical parameters affecting the push-pull character and intramolecular charge transfer (ICT) of the studied compounds have been investigated and compounds with enhanced hyperpolarizability β have been predicted. The benzothiazolium salts were found to be much more effective NLO-phores in comparison with the corresponding neutral benzothiazoles. The 4-NPh2 group is the most effective donor. The extension of conjugated bridge improves the studied NLO characteristics. An additional acceptor group bonded to the heterocycle causes a red shift of λmax but does not increase hyperpolarizability.
