16281-95-1

Usage

Appearance

White solid Describes the physical form and color of the compound, which is a white solid.

Use as intermediate

Synthesis of pharmaceuticals and agrochemicals The compound serves as a starting material or building block in the production of various pharmaceutical and agrochemical products.

Importance in organic chemistry

Building block The compound is a key component in the creation of other organic compounds, making it valuable in the field of organic chemistry.

Industrial applications

Reactivity and versatility The compound's ability to react with other substances and its adaptability make it useful in various industrial processes.

Utilization in new compound development

Various industries The compound is widely used in the research and development of new chemical products for a range of industries.

Upstream product

• 50604-01-8 ethyl-benzoic acid methyl ester 
• 578-54-1 ortho-ethylaniline 
• 612-19-1 2-ethylbenzoic acid 
• 76118-05-3 2-ethylbenzoyl chloride 
• 34136-59-9 o-ethylbenzonitrile 
• 118-90-1 ortho-methylbenzoic acid 

Downstream Products

• 92552-45-9 2-phenyl-3-methylisoindolin-1-one 

Relevant academic research and scientific papers

One-pot method to construct isoindolinones and its application to the synthesis of DWP205109 and intermediate of Lenalidomide

Herein a practical and efficient system for concise synthesis of isoindolinones is described by using substituted methyl 2-(halomethyl)benzoates and substituted amines. Structurally various methyl 2-(halomethyl)benzoates and amines were transformed into isoindolinones 80–99% yield and purity in catalyst-free and solvent-free conditions. The method has a wide substrate scope. The synthetic utility of the one-pot reaction was demonstrated by the concise syntheses of Lenalidomide intermediate and DWP205190.

Protoberberins from Reissert Compounds VI [1]. Diastereoselective Synthesis and Relative Configuration of 2-Benzoyl-1-cyano-1-(1-phenylalkyl)-1,2-dihydroisoquinolines

The alkylation of Reissert compounds 8 by sec-benzyl bromides 4, 7, and 10 diastereoselectively affords the title compounds 11 and 12. X-Ray structure analysis confirms an opposite configuration of the chiral centers in 11 and 12. The benzyl bromides 4, 7, and 10 are prepared by standard procedures.

Substituted 9,10-dihydroanthracen-9,10-imines

Substituted 9,10-dihydroanthracen-9,10-imines are disclosed to be minor tranquilizers, anticonvulsnts, muscle relaxants, and to be useful in the treatment of extrapyramidal disorders such as Parkinson's disease; also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions.