16282-71-6Relevant articles and documents
Comparative study of the reactions of n-BuMgBr and n-BuLi with cyclododecanone
Zakharkin, L. I.,Churilova, I. M.,Petrovskii, P. V.
, p. 863 - 865 (2007/10/02)
The composition of the products obtained in the reaction of n-BuMgBr and n-BuLi with cyclododecanone (1) has revealed that 1 exhibits the properties of a sterically hindered ketone.The highest yield of 1-butylcyclododecanol (2) was achieved with the use of n-BuMgBr, but in this case cyclododecanol was also formed, whereas the use of n-BuLi led to the tertiary alcohol more distinctly.Dehydration of alcohol 2 resulted in a mixture of three olefins containing up to 90percent of E- and Z- isomers of 1-butylcyclododecene.