1628200-44-1Relevant articles and documents
Catalytic One-Step Deoxytrifluoromethylation of Alcohols
Azambuja, Francisco De,Lovrien, Sydney M.,Ross, Patrick,Ambler, Brett R.,Altman, Ryan A.
, p. 2061 - 2071 (2019/05/16)
A new bench-stable trifluoromethylation reagent, phenyl bromodifluoroacetate, converts readily available alcohols to trifluoromethanes in a Cu-catalyzed deoxytrifluoromethylation reaction. This reaction streamlines access to target biologically active molecules, and should be useful for a variety of medicinal, agricultural, and materials chemists.
Copper-catalyzed decarboxylative trifluoromethylation of propargyl bromodifluoroacetates
Ambler, Brett R.,Peddi, Santosh,Altman, Ryan A.
, p. 1938 - 1946 (2014/07/22)
The development of efficient methods for accessing fluoA rinated functional groups is desirable. Herein, we report a two step method that utilizes catalytic copper for the decarboxylative trifluoromethylation of propargyl bromodifluoroacetates is described. This protocol affords a mixture of propargyl trifluoromethanes and trifluoromethyl allenes. Georg Thieme Verlag Stuttgart New York.