1628218-63-2Relevant academic research and scientific papers
Copper-catalyzed fluoroalkylation of alkynes, and alkynyl & vinyl carboxylic acids with fluoroalkyl halides
Ma, Jing-Jing,Yi, Wen-Bin
, p. 4295 - 4299 (2017)
Copper-catalyzed fluoroalkylation of alkynes and alkynyl carboxylic acids has been achieved with high functional-group tolerance and excellent regio- and stereoselectivities. A variety of fluoroalkyl halides including ethyl bromodifluoroacetate can be employed. Additionally, an unprecedented decarboxylative fluoroalkylation of α, β-unsaturated carboxylic acids has been achieved via a radical pathway.
Copper-mediated direct functionalization of unsaturated C-C bonds with ethyl bromo(difluoro)acetate: A straightforward access to highly valuable difluoromethylated alkenes
Belhomme, Marie-Charlotte,Dru, Delphine,Xiong, Heng-Ying,Cahard, Dominique,Besset, Tatiana,Poisson, Thomas,Pannecoucke, Xavier
supporting information, p. 1859 - 1870 (2014/07/22)
A copper-mediated fluorofunctionalization of alkenes and alkynes has been developed. This method provides ready access to trisubstituted difluoromethylated olefins (from dihydropyrans, glycal derivatives, or terminal alkynes) or to tetrasubstituted olefins (from disubstituted alkynes). The products were obtained in good to high yields with acceptable E/Z selectivities. Finally, a first direct route to difluoromethylated alkynes is reported, albeit with low yields. Georg Thieme Verlag Stuttgart New York.
