1628316-74-4

Basic information

• Product Name: MI-136
• Synonyms: MI-136;HY-19319 (MI 136;1H-Indole-2-carbonitrile, 5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-;5-[[4-[[6-(2,2,2-Trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-1H-indole-2-carbonitrile;5-((4-((6-(2,2,2-Trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-in
• CAS NO: 1628316-74-4
• Molecular Formula: C23H21F3N6S
• Molecular Weight: 470.52
• Mol File: 1628316-74-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 654.9±55.0 °C(Predicted)
• Appearance: /
• Density: 1.45±0.1 g/cm3(Predicted)
• PKA: 14.20±0.30(Predicted)
• CAS DataBase Reference: MI-136(CAS DataBase Reference)
• NIST Chemistry Reference: MI-136(1628316-74-4)
• EPA Substance Registry System: MI-136(1628316-74-4)

Safety Data

• Hazardous Substances Data: 1628316-74-4(Hazardous Substances Data)

Usage

Description

MI-136 is an inhibitor of the menin-MLL interaction (IC50 = 31 nM; Kd = 23.6 nM). By blocking MLL recruitment predominantly at the level of the menin-MLL interaction, it can inhibit androgen receptor (AR)-mediated transcription. At 40 mg/kg, MI-136 has been shown to block AR signaling, inhibiting the growth of castration-resistant tumors in mice.