162854-37-7

Basic information

• Product Name: Dibenzo[a,g]quinolizinium,5,6-dihydro-2,3,9,10-tetrahydroxy-
• Synonyms: 2,3,9,10-Tetrahydroxyberberine; 2,3-Desmethylene-9,10-desmethylberberine; 9,10-Di-O-demethyl-2,3-O-demethyleneberberine
• CAS NO: 162854-37-7
• Molecular Formula: C₁₇H₁₄NO₄
• Molecular Weight: 296.30
• Mol File: 162854-37-7.mol

Chemical Properties

• CAS DataBase Reference: Dibenzo[a,g]quinolizinium,5,6-dihydro-2,3,9,10-tetrahydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Dibenzo[a,g]quinolizinium,5,6-dihydro-2,3,9,10-tetrahydroxy-(162854-37-7)
• EPA Substance Registry System: Dibenzo[a,g]quinolizinium,5,6-dihydro-2,3,9,10-tetrahydroxy-(162854-37-7)

Safety Data

• Hazard Codes: A poison

Upstream product

• 633-65-8 berberine chloride 
• 2086-83-1 berberine 

Downstream Products

• 3486-67-7 palmatine 

Relevant articles and documents

Gastric-mucous membrane protection activity of coptisine derivatives

Coptisine and 8-oxocoptisine were isolated as principles of the gastric-mucous membrane protection from Coptidis rhizoma. The two compounds showed stronger activity than cimetidine and sucralfate. We prepared several derivatives having a partial structure of coptisine from commercially available starting materials. The compounds obtained were tested for gastric-mucous membrane protective activity and a correlation between activity and structure was studied. Our results suggest that the partial charge of the catechol skeleton is related to activity.

Compounds and Compositions for Modulating Lipid Levels and Methods of Preparing Same

The present technology relates to compounds of Formulas I-VI and methods of making and using such compounds. Methods of use include prevention and treatment of hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, hepatic steatosis, and metabolic syndrome. Compounds disclosed herein also increase HDL-C, lower total cholesterol, LDL-cholesterol, and triglycerides and increase hepatic LDL receptor expression, inhibit PCSK9 expression, and activate AMP-activated protein kinase.