16286-25-2

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 99-61-6 3-nitro-benzaldehyde 
• 119-65-3 isoquinoline 
• 70-11-1 α-bromoacetophenone 
• 110-86-1 pyridine 
• 100-11-8 1-bromomethyl-4-nitro-benzene 

Downstream Products

• 131447-62-6 1,7,7-Trimethyl-4-(3-nitro-phenyl)-4,6,7,8-tetrahydro-1H,3H-quinoline-2,5-dione 
• 423120-04-1 2-methyl-4-(3-nitro-phenyl)-6-oxo-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid 
• 1309444-73-2 3-(2-aminoethyl)-5-(3-(3-nitrophenyl)propylidene)thiazolidine-2,4-dione 
• 198783-53-8 3-(3-nitrophenyl)propanal 
• 1370550-62-1 N-cyclohexyl-2-(2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(3-nitrophenyl)acetamide 
• 64573-33-7 2-(3-nitrophenyl)-1H-perimidine 
• 1131626-01-1 dimethyl 3-(3-nitrophenyl)-6,6-dimethyl-5,7-dioxa-4,8-dioxospiro[2,5]octane-2,2-dicarboxylate 
• 128839-31-6 7,7-dimethyl-2,5-dioxo-4-(3'-nitrophenyl)-1,2,3,4,5,6,7,8-octahydroquinoline 

Relevant academic research and scientific papers

Water assisted and choline chloride-dimethylurea deep eutectic salts as catalyst towards the attractive reaction of indole, benzaldehyde, and malononitrile

The condensation of indole, benzaldehyde, and malononitrile was relatively rigorous compared with other Yonemitsu type reaction. We described a strategy using catalytic amount of choline chloride-dimethylurea deep eutectic salts as cheap and safe accelerator. We also found that introducing right amount of water in reaction system was crucial. This method tolerates variations in all three components to get desired 3-substituted indoles in satisfactory yields.

3,5-Disubstituted-thiazolidine-2,4-dione analogs as anticancer agents: Design, synthesis and biological characterization

A series of 2,5-disubstituted-thiazolidine-2,4-dione analogs based on the newly identified lead 1, a potential anticancer agent via the inhibition of the Raf/MEK/extracellular signal regulated kinase (ERK) and phosphatidylinositol 3-kinase (PI3K)/Akt signaling cascades, were synthesized and biologically characterized. A new lead structure, 15, was identified to have improved anti-proliferative activities in U937 cells, to induce apoptosis in U937, M12 and DU145 cancer cells, and to arrest U937 cells at the S-phase. Furthermore, Western blot analysis demonstrated a correlation of the anti-proliferative activity and blockade of the Raf/MEK/ERK and PI3K/Akt signaling pathways. Collectively, these results strongly encourage further optimization of 15 as a new lead with multi-target properties to develop more potent compounds as anticancer agents.

Synthesis of zwitterionic salts of pyridinium-meldrum acid and barbiturate through unique four-component reactions

An efficient synthetic procedure for the preparation of the unusual charge-separated pyridinium-Meldrum acid and N,N-dimethylbarbiturate acid zwitterionic salts was developed though a unique one-pot fourcomponent reaction involving pyridine, aromatic aldehyde, Meldrum acid or N,N-dimethylbarbituric acid, and p-nitrobenzyl bromide in acetonitrile. By varying combinations of four components involving nitrogencontaining heterocycles, we conveniently established reactiveα-halomethylene compounds, aldehydes and β-dicarbonyl compounds a library of zwitterionic salts.

Uncatalyzed Knoevenagel condensation in PEG-600 at room temperature

A rapid, efficient, and ecofriendly protocol has been developed for the Knoevenagel condensation of active methylene compounds with aromatic, aliphatic, conjugated and heteroaromatic aldehydes in polyethylene glycol-600 (PEG-600) with good to excellent yi

An efficient microwave-assisted synthesis of 3,5-unsubstituted 4-substituted-6-aryl-3,4-dihydropyridin-2(1H)-ones derivatives

(Chemical Equation Presented) Small libraries of 3,5-unsubstituted 4-substituted-6-aryl-3,4-dihydropyridin-2(1H)-ones derivatives were synthesized from the condensation-products of aldehydes with Meldrum's acid, aromatic ketones and ammonium acetate using

Kinetic studies of condensation of aromatic aldehydes with Meldrum's acid

The condensation reaction of Meldrum's acid with aromatic aldehydes in the presence of a catalyst has been investigated spectrophotometrically at 25-50 °C. The reaction follows overall second order kinetics, first order in each of the reactants. Electron-

3-Ureidobenzodiazepinones useful as antagonists of CCK or of gastrin

This invention relates to compounds having formula (I), STR1 wherein R1 is a hydrogen or halogen atom or an alkyl, alkoxy, alkylthio, nitro, hydroxy or cyano radical; R2 is an alkyl radical or a chain --CH(R5)--CO--R6