1628629-81-1Relevant articles and documents
Ring transformation of the S-(2-oxo-2,3-dihydro-1-benzofuran- 3-yl)isothiuronium bromides to 5-(2-hydroxyphenyl)- 2-imino-1,3-thiazolidin-4- ones
Kammel, Richard,Hanusek, Jiri
, p. 1183 - 1194 (2014/05/20)
Synthesis of thirteen substituted 5-(2-hydroxyethyl)-2-phenylimino- 1,3-thiazolidin-4-ones is described starting from easily available and stable S-(2-oxo-2,3-dihydro-1-benzofuran-3-yl)isothiuronium bromides. The transformation proceeds under mild conditions, is very simple to perform, and is applicable to a wide range of substituents on isothiuronium moiety. Some 1,3-thiazolidin-4-ones show dynamic NMR behavior in solution because of prototropy tautomerism and E-/Z-stereoisomerism. Thermochromic behavior was observed for all synthesized compound.