Palbociclib-d8 is a deuterated form of the drug palbociclib, a medication used for the treatment of hormone receptor-positive and human epidermal growth factor receptor 2-negative advanced breast cancer. Palbociclib-d8 is specifically labeled with deuterium, a stable isotope of hydrogen, at the C8 position. The process of deuteration, which involves the replacement of hydrogen atoms with deuterium, can potentially enhance the efficacy, safety, and pharmacokinetic properties of the drug. Deuterated drugs like palbociclib-d8 are being developed to improve the pharmacological profiles of existing drugs, offering potential benefits such as reduced dosing frequency and improved patient outcomes.
1628752-83-9
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Basic information
- Product Name: Palbociclib-d8
- Synonyms: Palbociclib-d8
- CAS NO:1628752-83-9
- Molecular Formula:
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1628752-83-9.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: N/A
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: Palbociclib-d8(CAS DataBase Reference)
- NIST Chemistry Reference: Palbociclib-d8(1628752-83-9)
- EPA Substance Registry System: Palbociclib-d8(1628752-83-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1628752-83-9(Hazardous Substances Data)
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1628752-83-9 Usage
Uses
Used in Pharmaceutical Industry:Palbociclib-d8 is used as a research and development tool for enhancing the pharmacological profile of the original drug palbociclib. The incorporation of deuterium at the C8 position aims to improve the drug's efficacy, safety, and pharmacokinetic properties, which can lead to better treatment outcomes for patients with advanced breast cancer.
Additionally, palbociclib-d8 can be utilized in various applications within the pharmaceutical industry, such as:
1. As a reference material for quality control and assurance processes, ensuring the consistency and purity of the drug.
2. In preclinical and clinical studies to compare the pharmacological effects of the deuterated and non-deuterated forms of palbociclib.
3. As a potential alternative treatment option for patients who may benefit from the improved properties of deuterated drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 1628752-83-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,2,8,7,5 and 2 respectively; the second part has 2 digits, 8 and 3 respectively.Calculate Digit Verification of CAS Registry Number 1628752-83:
(9*1)+(8*6)+(7*2)+(6*8)+(5*7)+(4*5)+(3*2)+(2*8)+(1*3)=199
199 % 10 = 9
So 1628752-83-9 is a valid CAS Registry Number.
1628752-83-9Upstream product
1628752-83-9Downstream Products
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Palbociclib-d8
