1629166-50-2Relevant academic research and scientific papers
Substrates as Electron-Donor Precursors: Synthesis of Naphtho-Fused Oxindoles via Benzannulation of 2-Halobenzaldehydes and Indolin-2-ones
Jia, Feng-Cheng,Xu, Cheng,Zhou, Zhi-Wen,Cai, Qun,Wu, Yan-Dong,Wu, An-Xin
, p. 5232 - 5235 (2016/11/02)
An unusual benzannulation reaction has been realized by integrating intermolecular adol condensation with subsequent intramolercular base-promoted homolytic aromatic substitution. This novel cascade reaction provides a straightforward approach toward various naphtho-fused oxindoles from 2-halobenzaldehydes and indolin-2-ones in the presence of Cs2CO3 in DMSO. The enolates of indolin-2-ones as new and internal electron donors have been demonstrated to initiate intramolecular radical dehalogenative coupling.
Catalyst-free one-pot tandem reduction of oxo and ene/yne functionalities by hydrazine: Synthesis of substituted oxindoles from isatins
Jha, Mukund,Shelke, Ganesh M.,Kumar, Anil
, p. 3334 - 3336 (2014/06/09)
An unprecedented one-pot tandem reduction of oxo and ene/yne functionalities of substituted isatins is disclosed for the synthesis of oxindole derivatives in excellent yields. The reaction is simply performed by treating N-(2-alkenyl)/propargylisatins wit
