162919-37-1

Basic information

• Product Name: (S)-3-(4'-BENZYLOXYPHENYL)-2-HYDROXY-PROPIONIC ACID
• Synonyms: (S)-3-(4-(Benzyloxy)phenyl)-2-hydroxypropanoic acid;Benzenepropanoic acid, .alpha.-hydroxy-4-(phenylmethoxy)-, (.alpha.S)-
• CAS NO: 162919-37-1
• Molecular Formula: C₁₆H₁₆O₄
• Molecular Weight: 272.3
• Mol File: 162919-37-1.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (S)-3-(4'-BENZYLOXYPHENYL)-2-HYDROXY-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(4'-BENZYLOXYPHENYL)-2-HYDROXY-PROPIONIC ACID(162919-37-1)
• EPA Substance Registry System: (S)-3-(4'-BENZYLOXYPHENYL)-2-HYDROXY-PROPIONIC ACID(162919-37-1)

Safety Data

• Hazardous Substances Data: 162919-37-1(Hazardous Substances Data)

Usage

General Description

(S)-3-(4'-benzyloxyphenyl)-2-hydroxy-propionic acid, also known as (S)-2-hydroxy-3-(4-benzyloxyphenyl)propionic acid, is a chemical compound with a molecular formula of C16H16O4. It is a chiral compound that is commonly used as a building block in the synthesis of pharmaceuticals and organic compounds. (S)-3-(4'-BENZYLOXYPHENYL)-2-HYDROXY-PROPIONIC ACID has a hydroxy group and a carboxylic acid group, making it useful in various chemical reactions and organic synthesis processes. It is also used as a chiral auxiliary in asymmetric synthesis and as a ligand in metal-catalyzed reactions. Additionally, it has potential pharmacological properties and may have applications in the development of new drugs.

Upstream product

• 156-39-8 4-hydroxyphenylpiruvic acid 
• 100-44-7 benzyl chloride 
• 2130-96-3 O-benzyl-N-tert-butoxycarbonyl-L-tyrosine 
• 60-18-4 L-tyrosine 
• 100-39-0 benzyl bromide 
• 63769-00-6 (S)-1-(1H-benzimidazol-2-yl)-2-(4-benzyloxy-phenyl)-ethylammonium trifluoro-acetate 
• 1431505-87-1 (E/Z)-methyl 3-(4-benzyloxyphenyl)-2-dimethylaminoacrylate 
• 1431505-92-8 methyl 3-(4-benzyloxyphenyl)-2-hydroxyacrylate 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 1431505-99-5 (Z)-methyl 3-(4-benzyloxyphenyl)-2-pivaloyloxyacrylate 
• 267228-34-2 (S)-2-acetyloxy-3-(4-benzyloxyphenyl)propionic acid 
• 23508-35-2 (S)-2-hydroxy-3-(4-hydroxy-phenyl)-propionic acid 

Downstream Products

• 251454-50-9 ethyl (2S)-3-[4-(benzyloxy)phenyl]-2-ethoxypropanoate 
• 1141933-39-2 (2S,4S)-4-(4-benzyloxybenzyl)-2-phenyl-5-oxodioxolane 
• 1141933-40-5 (2R,4S)-4-(4-benzyloxybenzyl)-2-phenyl-5-oxodioxolane 
• 22805-47-6 (S)-3-[4-(benzyloxy)phenyl]propane-1,2-diol 
• 1242104-15-9 (S)-2-((S)-2-(benzyloxy)-3-(4-(benzyloxy)phenyl)propanamido)-3-phenylpropanoic acid 
• 1242104-28-4 (S)-2-(benzyloxy)-3-(4-(benzyloxy)phenyl)propanoic acid 
• 1242104-26-2 benzyl 12-((2S,3aS,6R,7aS)-1-((S)-2-((S)-2-(benzyloxy)-3-(4-(benzyloxy)phenyl)propanamido)-3-phenylpropanoyl)-6-hydroxyoctahydro-1H-indol-2-yl)-3,12-dioxo-1-phenyl-2-oxa-4,6,11-triazadodecan-5-ylidenecarbamate 
• 1242104-25-1 (2S,3aS,6R,7aS)-2-(4-azidobutylcarbamoyl)-1-((S)-2-((S)-2-(benzyloxy)-3-(4-(benzyloxy)phenyl)propanamido)-3-phenylpropanoyl)octahydro-1H-indol-6-yl acetate 
• 1242104-24-0 (2S,3aS,6R,7aS)-1-((S)-2-((S)-2-(benzyloxy)-3-(4-(benzyloxy)phenyl)propanamido)-3-phenylpropanoyl)-2-(4-(methylsulfonyloxy)butylcarbamoyl)octahydro-1H-indol-6-yl acetate 
• 1262034-92-3 C₄₇H₅₅N₃O₈ 
• 1242104-17-1 (2S,3aS,6R,7aS)-1-((S)-2-((S)-2-(benzyloxy)-3-(4-(benzyloxy)phenyl)propanamido)-3-phenylpropanoyl)-2-(4-(tert-butyldiphenylsilyloxy)butylcarbamoyl)octahydro-1H-indol-6-yl acetate 
• 1242104-23-9 (2S,3aR,5R,6S,7aS)-6-acetoxy-1-((S)-2-((S)-2-(benzyloxy)-3-(4-(benzyloxy)phenyl)propanamido)-3-phenylpropanoyl)-2-(4-(tert-butyldiphenylsilyloxy)butylcarbamoyl)octahydro-1H-indol-5-yl 3-(trifluoromethyl)benzoate 

Relevant articles and documents

Stereoselective Modification of N-(α-Hydroxyacyl)-glycinesters via Palladium-Catalyzed Allylic Alkylation

N-(α-Hydroxyacyl)-glycinesters can be used as excellent nucleophiles in Pd-catalyzed allylic alkylation. The method allows for the stereoselective introduction of a wide range of side chains, including highly functionalized ones. Both diastereomers can be accessed through variation of the reaction conditions. Furthermore, the use of stannylated carbonates introduces vinylstannane motifs, which are eligible for subsequent C-C coupling reactions.

A PROCESS FOR PREPARATION OF PYRROLES HAVING HYPOLIPIDEMIC HYPOCHOLESTEREMIC ACTIVITIES

The present invention provides pyrroles having hypolipidemic hypocholesteremic activities. The invention provides saroglitazar and its pharmaceutically acceptable salts, hydrates, solvates, polymorphs or intermediates thereof. The invention also provides a process for the preparation of saroglitazar. The invention further provides intermediates as well process for preparation thereof.

Facile synthesis of α-hydroxy carboxylic acids from the corresponding α-amino acids

An effective and improved procedure is developed for the synthesis of α-hydroxy carboxylic acids by treatment of the corresponding protonated α-amino acid with tert-butyl nitrite in 1,4-dioxane-water. The amino moiety must be protonated and located α to a carboxylic acid function in order to undergo initial diazotization and successive hydroxylation, since neither β-amino acids nor acid derivatives such as esters and amides undergo hydroxylations. The method is successfully applied for the synthesis of 18 proteinogenic amino acids.