162922-16-9

Upstream product

• 94-74-6 MCPA 
• 1878-49-5 o-methylphenoxyacetic acid 
• 102-71-6 triethanolamine 

Downstream Products

• 186552-02-3 (4-cyano-2-methylphenoxy)acetic acid methyl ester 
• 870195-29-2 (4-{4-[2-(2,4-dichloro-phenoxy)-ethyl-carbamoyl]-5-phenyl-isoxazol-3-yl}-2-methyl-phenoxy)-acetic acid methyl ester 
• 870195-27-0 [4-(hydroxyimino-methyl)-2-methyl-phenoxy]-acetic acid methyl ester 
• 476156-34-0 (4-formyl-2-methyl-phenoxy)-acetic acid methyl ester 
• 317319-10-1 methyl (4-hydroxy-2-methylphenoxy)acetate 

Relevant academic research and scientific papers

Tris(2-hydroxyethyl)ammonium 4-halo-2-methylphenoxyacetates (halocresacins)

Convenient and efficient procedures have been developed for the synthesis of tris(2-hydroxyethyl)-ammonium 4-halo-2-methylphenoxyacetates (halocresacins). 4-Chloro-2-methylphenoxyacetic acid necessary for the preparation of chlorocresacin has been obtained by chlorination of 2-methylphenoxyacetic acid with sulfuryl chloride in the presence of aluminum powder. Bromocresacin has been synthesized by reaction of triethanolamine with 4-bromo-2-methylphenoxyacetic acid prepared by bromination of 2-methylphenoxyacetic acid with molecular bromine. Fluoro- and iodocresacins have been synthesized by exchange reaction of chlorocresacin with potassium fluoride and sodium iodide, respectively.

THIOPHENE DERIVATIVE PPAR MODULATORS

The present invention is directed to compounds represented by the following structural formula, Formula I: and stereoisomers, pharmaceutically acceptable salts, solvates and hydrates thereof, wherein: (a) X is selected from the group consisting of O, S, S(O)2, N, and a bond; (b) U is an aliphatic linker wherein one carbon atom of the aliphatic linker may be replaced with O, NH or S, and wherein such aliphatic linker is optionally substituted with R30; (c) Y is selected from the group consisting of C, O, S, NH and a single bond; and (d) E is C(R3)(R4)A or A.

Phototransformation of 4-chloro-2-methylphenoxy acetic acid (MCPA)

MCPA was irradiated in various conditions: in aqueous solution at different wavelengths, on silica in the absence of water, in the presence of TiO2 in aqueous suspension. In solution a wavelength effect was observed: the formation of 4-hydroxy-2-methylphen-oxyacetic acid is the main pathway at wavelengths shorter than 300 nm, whereas 4-chloro-2-methylphenol is the main product resulting from sunlight irradiation. Direct photolysis on silica and photocatalytic transformation mainly lead to the formation of 4-chloro-2-methylphenol. by Oldenbourg Wissenschaftsverlag, Mu?nchen.