162924-30-3Relevant articles and documents
Alkylation process for preparing azetidinone compound and starting compound therefor
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, (2008/06/13)
Novel process for preparing azetidinone compound of the formula [III]: STR1 wherein R1 is H or lower alkyl, R2 and R3 combine together with the adjacent nitrogen to form heterocyclic group, and R4 is protected or unprotected hydroxy-substituted lower alkyl, which comprises reacting an alkanamide compound of the formula [I]: STR2 wherein R1, R2 and R3 are the same as defined above, with a compound of the formula [II]: STR3 wherein L1 is a leaving group and R4 is the same as defined above, in the presence of a base, said compound [III] being useful as synthetic intermediate for 1-methylcarbapenem derivative having excellent antibacterial activity.