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162936-24-5

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162936-24-5 Usage

Chemical Properties

Off-White Solid

Uses

2-Iodo-5’-ethylcarboxamido-2’,3’-O-isopropylidineadenosine (cas# 162936-24-5) is a compound useful in organic synthesis.

Check Digit Verification of cas no

The CAS Registry Mumber 162936-24-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,2,9,3 and 6 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 162936-24:
(8*1)+(7*6)+(6*2)+(5*9)+(4*3)+(3*6)+(2*2)+(1*4)=145
145 % 10 = 5
So 162936-24-5 is a valid CAS Registry Number.

162936-24-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name N-ethyl-1'-deoxy-1'-(6-amino-2-iodo-9H-purin-9-yl)-2',3'-O-isopropylidene-β-D-ribofuranuronamide

1.2 Other means of identification

Product number -
Other names 2-IODO-5'-ETHYLCARBOXAMIDO-2',3'-O-ISOPROPYLIDINEADENOSINE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:162936-24-5 SDS

162936-24-5Relevant articles and documents

Linear and convergent approaches to 2-substituted adenosine-5′-N-alkylcarboxamides

Foitzik, Richard C.,Devine, Shane M.,Hausler, Nicholas E.,Scammells, Peter J.

experimental part, p. 8851 - 8857 (2009/12/26)

Herein we report both linear and convergent pathways for the preparation of 2-alkynyl substituted adenosine-5′-N-ethylcarboxamides via the versatile synthetic intermediate, 2-iodoadenosine-5′-N-ethylcarboxamide (13). The linear approach afforded 13 in an overall yield of 30% from guanosine over eight synthetic steps. The convergent approach was shorter, but proceeded in lower yield (five steps, 20% yield). Both approaches compare favourably with previously reported syntheses of 13, which has been prepared in 15% yield from guanosine over nine steps. 2-Iodoadenosine-5′-N-ethylcarboxamide (13) was subsequently converted to HENECA (2) and PHPNECA (3) to exemplify the utility of this approach for the preparation of?potent A2A adenosine receptor agonists. The linear approach was also amenable to the synthesis of 2-fluoropurine ribosides, which were subsequently elaborated into 2-alkylaminoadenosine-5′-N-ethylcarboxamides. Furthermore, both of these synthetic approaches are readily amenable to the synthesis of adenosine analogues with varied 2-, 6- and 5′-substitution patterns.

METHODS FOR PREPARING 2-ALKYNYLADENOSINE DERIVATIVES

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Page 18; 32, (2010/02/09)

Disclosed are methods for preparing 2-alkynyladenosine derivatives of Formula (A): or a stereoisomer, pharmaceutically acceptable salt, hydrate, solvate, acid salt hydrate or isomorphic crystalline form thereof, the method comprising the step ofcontacting

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