1629619-56-2Relevant academic research and scientific papers
Facile synthesis of spiro[indane-2,1′-pyrrolo[2,1-a ]isoquinolines] via three-component reaction of isoquinolinium salts, indane-1,3-dione, and isatins
Wang, Xiao-Hua,Yan, Chao-Guo
, p. 1059 - 1066 (2014)
A series of novel 2′-aryl-2′-(2-oxo-1,2-dihydro-3H-indol-3- ylidene)-2′,3′-dihydro-10b′H-spiro[indene-2, 1′-pyrrolo[2,1-a]isoquinoline]-1,3-diones were efficiently synthesized by three-component reactions of in situ generated N-phenacylisoquinolinium bromides with indane-1,3-dione and isatins in ethanol with triethylamine as the base. A domino reaction mechanism for the formation of the spiro compounds was rationally proposed. Georg Thieme Verlag Stuttgart New York.
