16297-06-6

Basic information

• Product Name: 2,3,5,6-TETRACHLOROISONICOTINONITRILE
• Synonyms: 2,3,5,6-TETRACHLOROISONICOTINONITRILE;2,3,5,6-TETRACHLOROPYRIDINE-4-CARBONITRILE
• CAS NO: 16297-06-6
• Molecular Formula: C₆Cl₄N₂
• Molecular Weight: 241.89
• Product Categories: Pyridines
• Mol File: 16297-06-6.mol

Chemical Properties

• Melting Point: 139-141
• Boiling Point: 298.3 °C at 760 mmHg
• Flash Point: 134.2 °C
• Appearance: /
• Density: 1.75 g/cm³
• Vapor Pressure: 0.00128mmHg at 25°C
• Refractive Index: 1.62
• CAS DataBase Reference: 2,3,5,6-TETRACHLOROISONICOTINONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,5,6-TETRACHLOROISONICOTINONITRILE(16297-06-6)
• EPA Substance Registry System: 2,3,5,6-TETRACHLOROISONICOTINONITRILE(16297-06-6)

Safety Data

• Hazard Codes: Xi
• Statements: R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.; R36/37/38:Irritating to eyes, respiratory system
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl
• Hazardous Substances Data: 16297-06-6(Hazardous Substances Data)

Usage

Uses

Used in Pesticide Industry:
2,3,5,6-Tetrachloroisonicotinonitrile is used as a pesticide for its potent insecticidal properties, effectively controlling a variety of pests that can damage crops and gardens. Its application is aimed at protecting plants from infestations, thereby ensuring a healthy and productive agricultural yield.
Used in Insecticide Applications:
In the realm of insect control, 2,3,5,6-Tetrachloroisonicotinonitrile serves as a critical component in insecticides, targeting insects that pose threats to both residential and commercial settings. Its use is justified by its ability to eliminate insects that can transmit diseases or cause structural damage.

InChI:InChI=1/C6Cl4N2/c7-3-2(1-11)4(8)6(10)12-5(3)9

Upstream product

• 70593-55-4 tetrachloro-isonicotinic acid amide 
• 100-48-1 pyridine-4-carbonitrile 

Downstream Products

• 16297-09-9 2,3,5,6-tetrafluoropyridine-4-carboxaldehyde 
• 87671-12-3 2-(3,5-dichloro-4-cyano-6-piperidinopyridin-2-yl)cyclohexanone 
• 87671-07-6 trichloro-4-cyano-6-(N-ethylanilino)pyridine 
• 87671-04-3 2,3,5-trichloro-4-cyano-6-morpholinopyridine 
• 87671-00-9 2-(trichloro-4-cyanopyridin-2-yl)cyclohexanone 
• 87670-96-0 2,3-dichloro-5-(5-chloro-3-oxapentyl)-4-cyano-6,7,8,9-tetrahydro-5H-pyrido<3,2-b>indole 
• 87671-01-0 2,3-dichloro-9-(5-chloro-3-oxapentyl)-4-cyano-5,6,7,8-tetrahydro-9H-pyrido<2,3-b>indole 

Relevant articles and documents

Synthesis of some fluorine-containing pyridinealdoximes of potential use for the treatment of organophosphorus nerve-agent poisoning

Fluoroheterocyclic aldoximes were screened as therapeutic agents for the treatment of anticholinesterase poisoning. 2-Fluoropyridine-3- and -6-aldoxime, and 3-fluoropyridine-2- and -4-aldoxime, were synthesised. Attempts to obtain 3,5,6-trifluoropyridine-2,4-bis(aldoxime) and -2-aldoxime, however, proved unsuccessful. Pentafluorobenzaldoxime was prepared by oximation of pentafluorobenzaldehyde. Acid dissociation constants (pKa) and second-order rate constants (kox-) of the fluorinated pyridinealdoximes towards sarin were measured. 2,3,5,6-Tetrafluoropyridine-4- aldoxime had the best profile: its kox- approached that of the therapeutic oxime P2S (310 vs. 120 l mol-1 min-1), but its higher pKa (9.1 vs. 7.8) fell short of the target figure of 8 required for reactivation of inhibited acetylcholinesterase in vivo. N-alkylation of the fluorinated pyridine-aldoximes may reduce their pK a nearer to 8 and enhance their therapeutic potential. Crown Copyright